Reviewed By
Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol (from 640 mg of Inositol Hexanicotinate)
135 mg
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Top Medical Research Studies
9
ITPP enhances heart attack recovery
We explored the potential of myo-inositol trispyrophosphate (ITPP) as a treatment for heart attacks and its effect on heart tissue injured by low oxygen levels. This research indicates ITPP modifies hemoglobin in red blood cells, enhancing the delivery of oxygen throughout the body.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
Read More
Most Useful Reviews
7.5
Clears blood vessels
2 people found this helpful
Due to coronary heart disease, I have significant blockages in my blood vessels. I know niacin aids in clearing these, and I've experienced minimal flushes. I trust its quality, and it hasn’t affected my allergies.
Read More
6
Improves heart health
2 people found this helpful
With coronary heart disease, I aim to enhance my cardiac circulatory system and manage cholesterol levels. This brand is straightforward to use, and I’ve experienced no adverse reactions with niacin or blood surges.
Read More
7.5
Supports heart health
1 people found this helpful
NOW Foods Niacin (Flush-Free) Double Strength is essential for my cardiovascular health. Since adding this double-strength supplement, I’ve seen improvements in my cholesterol and overall heart health.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
ITPP enhances heart attack recovery
We explored the potential of myo-inositol trispyrophosphate (ITPP) as a treatment for heart attacks and its effect on heart tissue injured by low oxygen levels. This research indicates ITPP modifies hemoglobin in red blood cells, enhancing the delivery of oxygen throughout the body.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Clears blood vessels
2 people found this helpful
Due to coronary heart disease, I have significant blockages in my blood vessels. I know niacin aids in clearing these, and I've experienced minimal flushes. I trust its quality, and it hasn’t affected my allergies.
Read More
6
Improves heart health
2 people found this helpful
With coronary heart disease, I aim to enhance my cardiac circulatory system and manage cholesterol levels. This brand is straightforward to use, and I’ve experienced no adverse reactions with niacin or blood surges.
Read More
7.5
Supports heart health
1 people found this helpful
NOW Foods Niacin (Flush-Free) Double Strength is essential for my cardiovascular health. Since adding this double-strength supplement, I’ve seen improvements in my cholesterol and overall heart health.
Read More
7.5
Regulates heart rhythm
I’ve taken Niacin for over two years, and it effectively treats my irregular heart rhythm.
Read More
6
Quality product
Good product from Now Foods. The package is compact with 180 veg capsules, though the 500mg dose is high. Recommended for improving heart health, but be aware of the niacin flush some experience at high doses.
Read More
Frequently Asked Questions
7.5
Supports heart health
1 people found this helpful
NOW Foods Niacin (Flush-Free) Double Strength is essential for my cardiovascular health. Since adding this double-strength supplement, I’ve seen improvements in my cholesterol and overall heart health.
7.5
Regulates heart rhythm
I’ve taken Niacin for over two years, and it effectively treats my irregular heart rhythm.
7.5
Clears blood vessels
2 people found this helpful
Due to coronary heart disease, I have significant blockages in my blood vessels. I know niacin aids in clearing these, and I've experienced minimal flushes. I trust its quality, and it hasn’t affected my allergies.
7.5
Good for heart care
This heart care supplement is effective and does not cause flushing, which is beneficial.
2
Beware of side effects
I took high-concentration niacin for cholesterol reduction, but after around 140 pills, I was diagnosed with suspected Brugada syndrome. After stopping, my arrhythmia improved, and my cholesterol levels dropped slightly, yet I'm concerned about the risks for my heart attack.
6
Improves heart health
2 people found this helpful
With coronary heart disease, I aim to enhance my cardiac circulatory system and manage cholesterol levels. This brand is straightforward to use, and I’ve experienced no adverse reactions with niacin or blood surges.
6
Quality product
Good product from Now Foods. The package is compact with 180 veg capsules, though the 500mg dose is high. Recommended for improving heart health, but be aware of the niacin flush some experience at high doses.
9
ITPP enhances heart attack recovery
We explored the potential of myo-inositol trispyrophosphate (ITPP) as a treatment for heart attacks and its effect on heart tissue injured by low oxygen levels. This research indicates ITPP modifies hemoglobin in red blood cells, enhancing the delivery of oxygen throughout the body.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
References
- Oknińska M, El-Hafny-Rahbi B, Paterek A, Mackiewicz U, Crola-Da Silva C, et al. Treatment of hypoxia-dependent cardiovascular diseases by myo-inositol trispyrophosphate (ITPP)-enhancement of oxygen delivery by red blood cells. J Cell Mol Med. 2020;24:2272. 10.1111/jcmm.14909
